mid-14c., "noon," from Old French meridien "of the noon time, midday; the Meridian; southerner" (12c.), and directly from Latin meridianus "of midday, of noon, southerly, to the south," from meridies "noon, south," from meridie "at noon," altered by dissimilation from pre-Latin *medi die, locative of medius "mid-" (from PIE root *medhyo- "middle") + dies "day" (from PIE root *dyeu- "to shine"). Cartographic sense first recorded late 14c. Figurative uses tend to suggest "point of highest development or fullest power."
The city in Mississippi, U.S., was settled 1854 (as Sowashee Station) at a railway junction and given its current name in 1860, supposedly by people who thought meridian meant "junction" (they perhaps confused the word with median).