"mathematical science," late 14c. as singular noun, mathematik (replaced since early 17c. by mathematics, q.v.), from Old French mathematique and directly from Latin mathematica (plural), from Greek mathēmatike tekhnē "mathematical science," feminine singular of mathēmatikos (adj.) "relating to mathematics, scientific, astronomical; pertaining to learning, disposed to learn," from mathēma (genitive mathēmatos) "science, knowledge, mathematical knowledge; a lesson," literally "that which is learnt;" from manthanein "to learn," from PIE root *mendh- "to learn."
As an adjective, "pertaining to mathematics," from c. 1400, from French mathématique or directly from Latin mathematicus.