mastiff (n.)

large, powerful breed of dog, early 14c., from Old French mastin "great cur, mastiff" (Modern French mâtin) or Provençal mastis, both from Vulgar Latin *mansuetinus "domesticated, tame," from Latin mansuetus "tame, gentle" (see mansuetude). Probably originally meaning a dog that stays in the house, thus a guard-dog or watchdog. Form in English perhaps influenced by Old French mestif "mongrel."

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