1918, altered by influence of Spanish proper name Maria Juana "Mary Jane" from mariguan (1894), from Mexican Spanish marihuana, which is of uncertain origin.
Marijuana ... makes you sensitive. Courtesy has a great deal to do with being sensitive. Unfortunately marijuana makes you the kind of sensitive where you insist on everyone listening to the drum solo in Iron Butterfly's 'In-a-Gadda-Da-Vida' fifty or sixty times. [P.J. O'Rourke, "Modern Manners," 1983]