1560s, "something made by hand," from Middle French manufacture, from Medieval Latin *manufactura (source of Italian manifattura, Spanish manufactura), from Latin manu, ablative of manus "hand" (from PIE root *man- (2) "hand") + factura "a working," from past participle stem of facere "to perform" (from PIE root *dhe- "to set, put"). Sense of "process of manufacturing" first recorded c. 1600. Related: Manufactures.
1680s, from manufacture (n.). Related: Manufactured; manufacturing; manufacturable.