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malignancy (n.)

c. 1600, "malignant nature;" 1650s, "state of extreme malevolence, bitter enmity," from malignant + abstract noun suffix -cy. Of diseases, growths, tumors, etc., "virulence, tendency to get worse," from 1680s. In English history, "adherence to the royal party in the time of Cromwell," 1640s, from malignants, a term applied to the royalists by their enemies.

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Definitions of malignancy

malignancy (n.)
(medicine) a malignant state; progressive and resistant to treatment and tending to cause death;
Synonyms: malignance
malignancy (n.)
quality of being disposed to evil; intense ill will;
Synonyms: malignity / malignance
From wordnet.princeton.edu