Etymology
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mainframe (n.)

"central processor of a computer system," 1964, from main (adj.) + frame (n.).

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Definitions of mainframe

mainframe (n.)
a large digital computer serving 100-400 users and occupying a special air-conditioned room;
Synonyms: mainframe computer
mainframe (n.)
(computer science) the part of a computer (a microprocessor chip) that does most of the data processing;
Synonyms: central processing unit / cpu / C.P.U. / central processor / processor
From wordnet.princeton.edu