Etymology
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madonna (n.)

1580s, Italian title of address or courtesy, equivalent to madam; from c. 1600 as a noun, "an Italian lady," from Italian madonna, from Old Italian ma donna (Italian mia donna) "my lady," from ma "my" + donna "lady," from Latin domina "lady, mistress of the house," from Latin domus "house" (from PIE root *dem- "house, household").

Often specifically "the Virgin Mary," hence the sense of "picture or statue of the Virgin Mary," attested in English by 1640s. The U.S. singer/dancer (full name Madonna Louise Ciccone, b. 1958) attained to pop stardom in the fall of 1984.

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Definitions of madonna

Madonna (n.)
the mother of Jesus; Christians refer to her as the Virgin Mary; she is especially honored by Roman Catholics;
Synonyms: Mary / Virgin Mary / The Virgin / Blessed Virgin
Madonna (n.)
United States pop singer and sex symbol during the 1980s (born in 1958);
Synonyms: Madonna Louise Ciccone
From wordnet.princeton.edu