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left-hander (n.)

1834, "a blow with the left hand," 1871, "left-handed person."

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Definitions of left-hander from WordNet

left-hander (n.)
a baseball pitcher who throws the ball with the left hand;
Synonyms: left-handed pitcher / left hander / lefthander / lefty / southpaw
left-hander (n.)
a person who uses the left hand with greater skill than the right;
Synonyms: lefty / southpaw
From wordnet.princeton.edu