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irritation (n.)

early 15c., irritacioun, in physiology, in reference to sores and morbid swelling, from Old French irritacion or directly from Latin irritationem (nominative irritatio) "incitement, stimulus; irritation, wrath, anger," noun of action from past-participle stem of irritare "to excite, provoke" (see irritate). Meaning "impatient or angry excitement" is from 1703.

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Definitions of irritation from WordNet

irritation (n.)
the psychological state of being irritated or annoyed;
irritation (n.)
a sudden outburst of anger;
Synonyms: pique / temper
irritation (n.)
(pathology) abnormal sensitivity to stimulation;
any food produced irritation of the stomach
irritation (n.)
the neural or electrical arousal of an organ or muscle or gland;
Synonyms: excitation / innervation
irritation (n.)
an uncomfortable feeling of mental painfulness or distress;
Synonyms: discomfort / soreness
irritation (n.)
unfriendly behavior that causes anger or resentment;
irritation (n.)
the act of troubling or annoying someone;
Synonyms: annoyance / annoying / vexation
From wordnet.princeton.edu