Etymology
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irremediable (adj.)

"beyond remedy," mid-15c., from Late Latin irremediabilis "incurable," from assimilated form of in- "not, opposite of" (see in- (1)) + remediabilis "that may be healed, curable" (see remediable).

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Definitions of irremediable

irremediable (adj.)
impossible to remedy or correct or redress;
irremediable defects of character
an irremediable error
From wordnet.princeton.edu