innervate (v.)

element meaning "into, in, on, upon" (also im-, il-, ir- by assimilation of -n- with following consonant), from Latin in- "in," from PIE root *en "in."

In Old French (and hence in Middle English) this often became en-, which in English had a strong tendency to revert to Latin in-, but not always, which accounts for pairs such as enquire/inquire. There was a native form, which in West Saxon usually appeared as on- (as in Old English onliehtan "to enlighten"), and some of those verbs survived into Middle English (such as inwrite "to inscribe"), but all now seem to be extinct.

Not related to in- (1) "not," which also was a common prefix in Latin, causing confusion: to the Romans impressus could mean "pressed" or "unpressed;" inaudire meant "to hear," but inauditus meant "unheard of;" in Late Latin investigabilis could mean "that may be searched into" or "that cannot be searched into." Latin invocatus was "uncalled, uninvited," but invocare was "to call, appeal to."

The trouble has continued in English; the hesitation over what is meant by inflammable being a commonly cited example. Implume (1610s) meant "to feather," but implumed (c. 1600) meant "unfeathered." Impliable can mean "capable of being implied" (1865) or "inflexible" (1734). Impartible in 17c. could mean "incapable of being divided" or "capable of being imparted." Impassionate can be "free from passion" or it can mean "strongly stirred by passion." Inanimate (adj.) is "lifeless," but Donne uses inanimate (v.) to mean "infuse with life or vigor." Irruption is "a breaking in," but irruptible is "unbreakable."

In addition to improve "use to one's profit," Middle English also had a verb improve meaning "to disprove" (15c.). To inculpate is "to accuse," but inculpable means "not culpable, free from blame." Infestive has meant "troublesome, annoying" (1560s, from infest) and "not festive" (1620s). In Middle English inflexible could mean "incapable of being bent" or "capable of being swayed or moved." In 17c., informed could mean "current in information," formed, animated," or "unformed, formless" ("This was an awkward use" [OED]). Inhabited has meant "dwelt in" (1560s) and "uninhabited" (1610s); inhabitable likewise has been used on opposite senses, a confusion that goes back to Late Latin.

late 14c., nerve, nerf, "sinew, tendon, hard cord of the body" (a sense now obsolete), also "fiber or bundle of fibers that convey the capacity to feel or move from the brain or spinal cord to the body," from Old French nerf and directly from Medieval Latin nervus "a nerve," from Latin nervus "sinew, tendon; cord, bowstring, string of a musical instrument," metathesis of pre-Latin *neuros, from PIE *(s)neu- "tendon, sinew" (source also of Sanskrit snavan- "band, sinew," Armenian neard "sinew," Greek neuron "sinew, tendon," in Galen "nerve").

The late medieval surgeons understood the nature and function of the nerves and often used nervus to denote a `nerve' in the modern sense, as well as to denote a `tendon'. There appears to have been some confusion, however, between nerves and tendons; hence, a number of instances in which nervus may be interpreted in either way or in both ways simultaneously. [Middle English Compendium] 

The secondary senses developed from meaning "strength, vigor; force, energy" (c. 1600), from the "sinew" sense. Hence the non-scientific sense with reference to feeling or courage, first attested c. 1600 (as in nerves of steel, 1869) and that of "coolness in the face of danger, fortitude under trying or critical circumstances" is by 1809. The bad sense "impudence, boldness, cheek" (originally slang) is by 1887. Latin nervus also had a figurative sense of "vigor, force, power, strength," as did Greek neuron. From the neurological sense come Nerves "condition of hysterical nervousness," attested by 1890, perhaps from 1792. To get on (someone's) nerves is from 1895. War of nerves "psychological warfare" is from 1915.

word-forming element used in forming nouns from Latin words ending in -atus, -atum (such as estate, primate, senate). Those that came to English via French often arrived with -at, but an -e was added after c. 1400 to indicate the long vowel. The suffix also can mark adjectives formed from Latin past participles in -atus, -ata (such as desolate, moderate, separate); again, they often were adopted in Middle English as -at, with an -e appended after c. 1400.