mid-15c., "cruel," from Latin inhumanus "inhuman, savage, cruel, rude, barbarous, uncultured," from in- "not, opposite of" (see in- (1)) + humanus "human" (see human (adj.)). Spelled inhumane till 18c. (see humane).
word-forming element meaning "not, opposite of, without" (also im-, il-, ir- by assimilation of -n- with following consonant, a tendency which began in later Latin), from Latin in- "not," cognate with Greek an-, Old English un-, all from PIE root *ne- "not."
In Old French and Middle English often en-, but most of these forms have not survived in Modern English, and the few that do (enemy, for instance) no longer are felt as negative. The rule of thumb in English has been to use in- with obviously Latin elements, un- with native or nativized ones.
mid-15c., humain, humaigne, "human," from Old French humain, umain (adj.) "of or belonging to man" (12c.), from Latin humanus "of man, human," also "humane, philanthropic, kind, gentle, polite; learned, refined, civilized." This is in part from PIE *(dh)ghomon-, literally "earthling, earthly being," as opposed to the gods (from root *dhghem- "earth"), but there is no settled explanation of the sound changes involved. Compare Hebrew adam "man," from adamah "ground." Cognate with Old Lithuanian žmuo (accusative žmuni) "man, male person."
Human interest is from 1824. Human rights attested by 1680s; human being by 1690s. Human relations is from 1916; human resources attested by 1907, American English, apparently originally among social Christians and based on natural resources. Human comedy "sum of human activities" translates French comédie humaine (Balzac); see comedy.