informed (adj.)

early 14c., "to train or instruct in some specific subject," from Old French informer, enformer "instruct, teach" (13c.) and directly from Latin informare "to shape, give form to, delineate," figuratively "train, instruct, educate," from in- "into" (from PIE root *en "in") + formare "to form, shape," from forma "form" (see form (n.)). In early use also enform until c. 1600. Sense of "report facts or news, communicate information to" first recorded late 14c. Related: Informed; informing.

word-forming element meaning "not, opposite of, without" (also im-, il-, ir- by assimilation of -n- with following consonant, a tendency which began in later Latin), from Latin in- "not," cognate with Greek an-, Old English un-, all from PIE root *ne- "not."

In Old French and Middle English often en-, but most of these forms have not survived in Modern English, and the few that do (enemy, for instance) no longer are felt as negative. The rule of thumb in English has been to use in- with obviously Latin elements, un- with native or nativized ones.