Etymology
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infest (v.)

late 15c., "to attack, assail, hurt, distress, annoy," from Old French infester (14c.), from Latin infestare "to attack, disturb, trouble," from infestus "unsafe, hostile, threatening, dangerous," originally "inexorable, not able to be handled," from in- "not, opposite of" (see in- (1)) + -festus, perhaps "(able to be) seized" (see manifest (adj.)). Sense of "swarm over in large numbers, attack parasitically" first recorded c. 1600. Related: Infested; infesting.

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Definitions of infest

infest (v.)
invade in great numbers;
the roaches infested our kitchen
Synonyms: overrun
infest (v.)
occupy in large numbers or live on a host;
the Kudzu plant infests much of the South and is spreading to the North
Synonyms: invade / overrun
infest (v.)
live on or in a host, as of parasites;
From wordnet.princeton.edu