1580s (implied in indefatigably), from French indefatigable (15c.), from Latin indefatigabilis "that cannot be wearied," from in- "not" (see in- (1)) + defatigare "to tire out," from de- "utterly, down, away" (see de-) + fatigare "to weary" (see fatigue (n.)).
Blount's "Glossographia" (1656) has defatigable, which also was in use elsewhere in 17c., but the modern use of defatigable (1948) probably is a jocular back-formation from indefatigable.
word-forming element making abstract nouns from adjectives and meaning "condition or quality of being ______," from Middle English -ite, from Old French -ete (Modern French -ité) and directly from Latin -itatem (nominative -itas), suffix denoting state or condition, composed of -i- (from the stem or else a connective) + the common abstract suffix -tas (see -ty (2)).
Roughly, the word in -ity usually means the quality of being what the adjective describes, or concretely an instance of the quality, or collectively all the instances; & the word in -ism means the disposition, or collectively all those who feel it. [Fowler]
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Harper, D. (n.d.). Etymology of indefatigability. Online Etymology Dictionary. Retrieved $(datetime), from https://www.etymonline.com/word/indefatigability