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incapacitate (v.)

1650s in a legal sense; 1660s in general use, "deprive of natural power," from incapacity + -ate. Related: Incapacitated; incapacitating.

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Definitions of incapacitate from WordNet

incapacitate (v.)
make unable to perform a certain action;
Synonyms: disable / disenable
incapacitate (v.)
injure permanently;
Synonyms: disable / invalid / handicap
From wordnet.princeton.edu