word-forming element meaning "under, beneath; less, less than" (in chemistry, indicating a lesser oxidation), from Greek hypo (prep. and adverb) "under, beneath; up from under; toward and under (i.e. into)," from PIE root *upo "under."
1640s, "relating to or characterized by muscular tension," from Greek tonikos "of stretching," from tonos "a stretching," from PIE root *ten- "to stretch." The meaning "maintaining the healthy firmness of tissues" is recorded from 1680s, first extended 1756 to "having the property of restoring to health." Related: Tonical (1580s).
Others are reading
Definitions of hypotonic from WordNet
(of living tissue) lacking normal tone or tension;
(of a solution) having a lower osmotic pressure than a comparison solution;