c. 1600, "offspring of plants or animals of different variety or species," from Latin hybrida, variant of ibrida "mongrel," specifically "offspring of a tame sow and a wild boar," of unknown origin but probably from Greek and somehow related to hubris. A rare word before the general sense "anything a product of two heterogeneous things" emerged c. 1850. The adjective is attested from 1716. As a noun meaning "automobile powered by an engine that uses both electricity and gasoline," 2002, short for hybrid vehicle, etc.
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