Etymology
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hecatomb (n.)

1590s, from Latinized form of Greek hekatombe, properly (and literally) "offering of 100 oxen," but generally "a great public sacrifice." It is a compound of hekaton "one hundred," which perhaps is dissimilation of *hem-katon, with hen, neuter of heis "one" + *katon "hundred." The second element is bous "ox" (from PIE root *gwou- "ox, bull, cow"). The first month of the Attic calendar (corresponding to July-August) was Hekatombaion, in which sacrifices were made.

updated on January 21, 2019

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Definitions of hecatomb from WordNet

hecatomb (n.)
a great sacrifice; an ancient Greek or Roman sacrifice of 100 oxen;
From wordnet.princeton.edu, not affiliated with etymonline.