Etymology
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handcuff (n.)

1640s as a decorative addition to a sleeve; 1690s as a type of restraining device, from hand (n.) + cuff (n.) in the "fetter for the wrist" sense (attested from 1660s). Old English had hondcops "a pair of hand cuffs," but the modern word is a re-invention. Related: Handcuffs. The verb is first attested 1720. Related: Handcuffed; handcuffing.

updated on June 01, 2018

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Definitions of handcuff from WordNet
1
handcuff (v.)
confine or restrain with or as if with manacles or handcuffs;
The police handcuffed the suspect at the scene of the crime
Synonyms: manacle / cuff
2
handcuff (n.)
shackle that consists of a metal loop that can be locked around the wrist; usually used in pairs;
Synonyms: cuff / handlock / manacle
Etymologies are not definitions. From wordnet.princeton.edu, not affiliated with etymonline.