hamartia (n.)

"tragic flaw," Greek, literally "fault, failure, guilt, sin" from hamartanein "to fail of one's purpose; to err, sin," originally "to miss the mark," from PIE *hemert- "to miss, fail." "The aspiration must be analogical. The word has no known cognates, but the reconstructed root looks perfectly IE" [Robert Beekes, "Etymological Dictionary of Greek"].

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