1590s, "a drain," from guzzle (v.). From 1704 as "liquor," 1836 as "bout of heavy drinking."
1570s, "swallow liquid greedily" (intransitive), 1580s in transitive sense, probably related to Old French gosillier "to go down the gullet; to vomit, chatter, talk," from gosier (13c.) "jaws, throat, gullet." Or imitative of the sound of drinking greedily. Related: Guzzled; guzzling.
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