Etymology
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guts (n.)

"spirit, courage," 1893, figurative plural of gut (n.). The idea of the bowels as the seat of the spirit goes back to at least mid-14c. (compare bowel).

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Definitions of guts

guts (n.)
fortitude and determination;
he didn't have the guts to try it
Synonyms: backbone / grit / moxie / sand / gumption
From wordnet.princeton.edu