1560s, "sudden and apparently causeless turn of mind," of unknown origin. Perhaps it is from a dialectal survival of a word related to Middle English friken "to move nimbly or briskly," from Old English frician "to dance" [OED, Barnhart]. There is a freking attested in mid-15c., apparently meaning "capricious behavior, whims." Or perhaps from Middle English frek "eager, zealous, bold, brave, fierce" (see freak (n.2)).
Sense of "capricious notion" (1560s) and "unusual thing, fancy" (1784) preceded that of "abnormally developed individual or production" (first in freak of nature, 1839, which was later popular in variety show advertisements for bearded ladies, albinos, etc.; compare Latin lusus naturæ, which was used in English from 1660s). As "drug user," attested from 1945. The sense in health freak, ecology freak, etc. is attested from 1908 (originally Kodak freak, a camera buff). Freak show attested from 1887.