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flu (n.)

1839, flue, shortening of influenza. Spelling flu attested from 1893. The abstraction of the middle syllable is an uncommon method of shortening words in English; Weekley compares tec for detective, scrip for subscription.

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Definitions of flu from WordNet

flu (n.)
an acute febrile highly contagious viral disease;
Synonyms: influenza / grippe
From wordnet.princeton.edu