Old English fætt "fat, fatted, plump, obese," originally a contracted past participle of fættian "to cram, stuff," from Proto-Germanic *faitida "fatted," from verb *faitjan "to fatten," from *faita- "plump, fat" (source also of Old Frisian fatt, Old Norse feitr, Dutch vet, German feist "fat"), from PIE *poid- "to abound in water, milk, fat, etc." (source also of Greek piduein "to gush forth"), from root *peie- "to be fat, swell" (source also of Sanskrit payate "swells, exuberates," pituh "juice, sap, resin;" Lithuanian pienas "milk;" Greek pion "fat; wealthy;" Latin pinguis "fat").
Meaning "abounding in comforts, prosperous" is late 14c. Teen slang meaning "attractive, up to date" (also later phat) is attested from 1951. Fat cat "privileged and rich person" is from 1928; fat chance "no chance at all" attested from 1905, perhaps ironic (the expression is found earlier in the sense "good opportunity"). Fathead is from 1842; fat-witted is from 1590s; fatso is first recorded 1943. Expression the fat is in the fire originally meant "the plan has failed" (1560s).
Spanish gordo "fat, thick," is from Latin gurdus "stupid, doltish; heavy, clumsy," which also is the source of French gourd "stiff, benumbed" (12c.), engourdir "to dull, stupefy, benumb" (13c.).
word-forming element making verbs (such as darken, weaken) from adjectives or nouns, from Old English -nian, from Proto-Germanic *-inojan (also source of Old Norse -na), from PIE adjectival suffix *-no-. Most active in Middle English and early modern English, hence most verbs in -en are comparatively recent.