Etymology
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fatigue (n.)

1660s, "that which causes weariness," from French fatigue "weariness," from fatiguer "to tire" (15c.), from Latin fatigare "to weary, to tire out," originally "to cause to break down," from pre-Latin adjective *fati-agos "driving to the point of breakdown," with first half from Old Latin *fatis, which is of unknown origin but apparently related to affatim (adv.) "sufficiently" and to fatisci "crack, split." The second half is the root of agere "to set in motion, drive; to do, perform" (from PIE root *ag- "to drive, draw out or forth, move").

Especially "the labors of military persons" (1776). Meaning "a feeling of weariness from exertion" is from 1719. Of metals or other materials under strain, from 1877.

fatigue (v.)

1690s, from French fatiguer "to tire" (15c.), from fatigue (see fatigue (n.)). Earlier in same sense was fatigate (1530s), from Latin fatigatus, past participle of fatigare. Related: Fatigued; fatiguing; fatigation (c. 1500).

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Definitions of fatigue
1
fatigue (n.)
temporary loss of strength and energy resulting from hard physical or mental work;
growing fatigue was apparent from the decline in the execution of their athletic skills
he was hospitalized for extreme fatigue
Synonyms: weariness / tiredness
fatigue (n.)
used of materials (especially metals) in a weakened state caused by long stress;
metal fatigue
fatigue (n.)
(always used with a modifier) boredom resulting from overexposure to something;
he was suffering from museum fatigue
political fatigue
the American public is experiencing scandal fatigue
after watching TV with her husband she had a bad case of football fatigue
fatigue (n.)
labor of a nonmilitary kind done by soldiers (cleaning or digging or draining or so on);
they were assigned to kitchen fatigues
the soldiers were put on fatigue to teach them a lesson
Synonyms: fatigue duty
2
fatigue (v.)
lose interest or become bored with something or somebody;
Synonyms: tire / pall / weary / jade
fatigue (v.)
exhaust or get tired through overuse or great strain or stress;
Synonyms: tire / wear upon / tire out / wear / weary / jade / wear out / outwear / wear down / fag out / fag
From wordnet.princeton.edu