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exacerbation (n.)

c. 1400, from Late Latin exacerbationem (nominative exacerbatio), noun of action from past participle stem of Latin exacerbare "exasperate, irritate, provoke," from ex, here probably "thoroughly" (see ex-), + acerbus "harsh, bitter," from acer "sharp, keen," from PIE root *ak- "be sharp, rise (out) to a point, pierce."