before vowels reduced to ep-, before aspirated vowels eph-, word-forming element meaning "on, upon, above," also "in addition to; toward, among," from Greek epi "upon, at, close upon (in space or time), on the occasion of, in addition," also "after," from PIE *epi, *opi "near, at, against" (source also of Sanskrit api "also, besides;" Avestan aipi "also, to, toward;" Armenian ev "also, and;" Latin ob "toward, against, in the way of;" Oscan op, Greek opi- "behind;" Hittite appizzis "younger;" Lithuanian ap- "about, near;" Old Church Slavonic ob "on"). A productive prefix in Greek; also used in modern scientific compounds (such as epicenter).
"tough outer membrane surrounding the brain and the spinal cord," c. 1400, from Medieval Latin dura mater cerebri, literally "hard mother of the brain," a loan-translation of Arabic umm al-dimagh as-safiqa, literally "thick mother of the brain." "In Arabic, the words 'father,' 'mother,' and 'son' are often used to denote relationships between things" [Klein].
D. Harper. “Etymology of epidural.” Online Etymology Dictionary. https://www.etymonline.com/word/epidural (accessed $(datetime)).
Definitions of epidural
regional anesthesia resulting from injection of an anesthetic into the epidural space of the spinal cord; sensation is lost in the abdominal and genital and pelvic areas; used in childbirth and gynecological surgery;