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enervation (n.)

early 15c., enervacion, "impairment, infringement," from Late Latin enervationem (nominative enervatio), noun of action from past-participle stem of Latin enervare "weaken," literally "cut the sinews of," from ex "out" (see ex-) + nervus "sinew" (see nerve (n.)). Figurative sense is from 1550s.

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Definitions of enervation from WordNet

enervation (n.)
lack of vitality;
an enervation of mind greater than any fatigue
enervation (n.)
serious weakening and loss of energy;
Synonyms: debilitation / enfeeblement / exhaustion
enervation (n.)
surgical removal of a nerve;
From wordnet.princeton.edu