"particular to a people or locality," 1650s (endemical), with -ic + Greek endemos "native, dwelling in (a place), of or belonging to a people," from en "in" (see en- (2)) + dēmos "people; district" (see demotic). From 1660s as a noun.
Middle English -ik, -ick, word-forming element making adjectives, "having to do with, having the nature of, being, made of, caused by, similar to," from French -ique and directly from Latin -icus or from cognate Greek -ikos "in the manner of; pertaining to." From PIE adjective suffix *-(i)ko, which also yielded Slavic -isku, adjectival suffix indicating origin, the source of the -sky (Russian -skii) in many surnames. In chemistry, indicating a higher valence than names in -ous (first in benzoic, 1791).
In Middle English and after often spelled -ick, -ike, -ique. Variant forms in -ick (critick, ethick) were common in early Modern English and survived in English dictionaries into early 19c. This spelling was supported by Johnson but opposed by Webster, who prevailed.
word-forming element meaning "near, at, in, on, within," from Greek en "in," cognate with Latin in (from PIE root *en "in"), and thus with en- (1). Typically assimilated to em- before -p-, -b-, -m-, -l-, and -r-.