enchiridion (n.)

word-forming element meaning "near, at, in, on, within," from Greek en "in," cognate with Latin in (from PIE root *en "in"), and thus with en- (1). Typically assimilated to em- before -p-, -b-, -m-, -l-, and -r-.

Proto-Indo-European root meaning "the hand." 

It forms all or part of: chiral; chiro-; chirognomy; chirography; chirology; chiromancy; chiropodist; chiropractic; chiropractor; chirosophy; chirurgeon; enchiridion; surgeon; surgery; surgical.

It is the hypothetical source of/evidence for its existence is provided by: Greek kheir, Hittite keshshar, Armenian jern "the hand" 

Old English handboc "handbook, manual;" see hand (n.) + book (n.). It translates Latin manualis, and was displaced in Middle English by manual (from French), and later in part by enchiridion (from Greek). Reintroduced 1814 in imitation of German Handbuch, but execrated through much of 19c. as "that very ugly and very unnecessary word" [Richard Chenevix Trench, "English Past and Present," 1905].