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embitter (v.)

c. 1600, from em- (1) + bitter (adj.). Now rare in its literal sense; figurative meaning first attested 1630s. Related: Embittered; embitterment.

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Definitions of embitter from WordNet

embitter (v.)
cause to be bitter or resentful;
These injustices embittered her even more
Synonyms: envenom / acerbate
From wordnet.princeton.edu