1560s, "cause to go down," from down (adv.). Meaning "swallow hastily" is by 1860; football sense of "bring down (an opposing player) by tackling" is attested by 1887. Figurative sense of "defeat, get the better of" is by 1898. Related: Downed; downing.
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Definitions of downer from WordNet
a drug that reduces excitability and calms a person;