disquisition (n.)

word-forming element of Latin origin meaning 1. "lack of, not" (as in dishonest); 2. "opposite of, do the opposite of" (as in disallow); 3. "apart, away" (as in discard), from Old French des- or directly from Latin dis- "apart, asunder, in a different direction, between," figuratively "not, un-," also "exceedingly, utterly." Assimilated as dif- before -f- and to di- before most voiced consonants.

The Latin prefix is from PIE *dis- "apart, asunder" (source also of Old English te-, Old Saxon ti-, Old High German ze-, German zer-). The PIE root is a secondary form of *dwis- and thus is related to Latin bis "twice" (originally *dvis) and to duo, on notion of "two ways, in twain" (hence "apart, asunder").

In classical Latin, dis- paralleled de- and had much the same meaning, but in Late Latin dis- came to be the favored form and this passed into Old French as des-, the form used for compound words formed in Old French, where it increasingly had a privative sense ("not"). In English, many of these words eventually were altered back to dis-, while in French many have been altered back to de-. The usual confusion prevails.

As a living prefix in English, it reverses or negatives what it is affixed to. Sometimes, as in Italian, it is reduced to s- (as in spend, splay, sport, sdain for disdain, and the surnames Spencer and Spence).

1530s, quaere "a question," from Latin quaere "to ask, inquire," "much used as a marginal note or memorandum to indicate a question or doubt, and hence taken as a noun" [Century Dictionary], second person singular imperative of quaerere "to seek, look for; strive, endeavor, strive to gain; ask, require, demand;" figuratively "seek mentally, seek to learn, make inquiry," probably ultimately from PIE root *kwo-, stem of relative and interrogative pronouns. Spelling Englished or altered c. 1600 by influence of inquiry. Compare quest.

Query stands for a question asked without force, a point about which one would like to be informed : the word is used with all degrees of weakness down to the mere expression of a doubt; as, I raised a query as to the strength of the bridge. [Century Dictionary]