Etymology
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disquietude (n.)

"uneasy or disturbed state of mind," 1709; from disquiet on model of quietude. Disquietness is from 1530s.

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Definitions of disquietude

disquietude (n.)
feelings of anxiety that make you tense and irritable;
Synonyms: edginess / uneasiness / inquietude
From wordnet.princeton.edu