"to upset, embarrass," 1834, discombobricate, American English, fanciful mock-Latin coinage of a type popular then. Compare, on a similar pattern, confusticate (1852), absquatulate (1840), spifflicate "confound, beat" (1850), scrumplicate "eat" (1890). Related: discombobulating; discombobulation.
Others are reading
Definitions of discombobulated from WordNet
having self-possession upset; thrown into confusion; "looked at each other dumbly, quite disconcerted"- G.B.Shaw;
the hecklers pelted the discombobulated speaker with anything that came to hand