Etymology
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despise (v.)

"look down upon, scorn, disdain, treat with contempt," c. 1300, despisen, from Old French despis-, present-participle stem of despire "to despise," from Latin despicere "look down on, scorn," from de- "down" (see de-) + spicere/specere "to look at" (from PIE root *spek- "to observe"). Related: Despised; despising.

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Definitions of despise

despise (v.)
look down on with disdain;
He despises the people he has to work for
Synonyms: contemn / scorn / disdain
From wordnet.princeton.edu