"that may be or deserves to be despised," 1550s, from Late Latin despicabilis, from Latin despicari "despise, disdain," which is related to despicere "to look down upon," from de- "down" (see de-) + spicere, variant of specere "to look at" (from PIE root *spek- "to observe"). Related: Despicability; despicably; despicableness.
would do something as despicable as murder
despair
despatch
desperado
desperate
desperation
despicable
despise
despite
despoil
despoliation
despond
