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depressant (n.)

"a sedative," 1876; see depress + -ant. From 1887 as an adjective, "having the quality of depressing."

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Definitions of depressant from WordNet
1
depressant (n.)
a drug that reduces excitability and calms a person;
Synonyms: sedative / sedative drug / downer
2
depressant (adj.)
capable of depressing physiological or psychological activity or response by a chemical agent;
From wordnet.princeton.edu