Etymology
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depopulation (n.)

early 15c., depopulacioun, "ravaging, pillaging, destruction," possibly also "destruction or expulsion of inhabitants," from Old French depopulacion and directly from Latin depopulationem (nominative depopulatio) "a laying waste, marauding, pillaging;" see de- + population.

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Definitions of depopulation

depopulation (n.)
the condition of having reduced numbers of inhabitants (or no inhabitants at all);
From wordnet.princeton.edu