Etymology
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denature (v.)

"alter (something) so as to change its nature," 1878, from French dénaturer (Old French desnaturer "change the nature of; make unnatural"); see de- + nature. Earlier it meant "to make unnatural" (1680s). Earlier in the modern sense of denature was denaturalize (1812). Related: Denatured.

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Definitions of denature

denature (v.)
add nonfissionable material to (fissionable material) so as to make unsuitable for use in an atomic bomb;
denature (v.)
modify (as a native protein) especially by heat, acid, alkali, or ultraviolet radiation so that all of the original properties are removed or diminished;
denature (v.)
make (alcohol) unfit for drinking without impairing usefulness for other purposes;
From wordnet.princeton.edu