Etymology
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curse (n.)

late Old English curs "a prayer that evil or harm befall one; consignment of a person to an evil fate," of uncertain origin. No similar word exists in Germanic, Romance, or Celtic. Middle English Compendium says probably from Latin cursus "course" (see course (n.)) in the Christian sense "set of daily liturgical prayers" extended to "set of imprecations" as in the sentence of the great curse, "the formula read in churches four times a year, setting forth the various offenses which entailed automatic excommunication of the offender; also, the excommunication so imposed."  Connection with cross is unlikely. Another suggested source is Old French curuz "anger."

Meaning "the evil which has been invoked upon one, that which causes severe trouble" is from early 14c. Curses as a histrionic exclamation ("curses upon him/her/it") is by 1680s. The curse in 19c. was the sentence imposed upon Adam and Eve in Genesis iii.16-19. The slang sense "menstruation" is from 1930. Curse of Scotland, the 9 of diamonds in cards, is attested from 1791, but the signification is obscure.

curse (v.)

Middle English cursen, from Old English cursian, "to wish evil to; to excommunicate," from the source of curse (n.). Intransitive meaning "swear profanely, use blasphemous or profane language" is from early 13c. (compare swear (v.)). The sense of "blight with malignant evils" is from 1590s. Related: Cursed; cursing.

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Definitions of curse
1
curse (n.)
profane or obscene expression usually of surprise or anger;
Synonyms: curse word / expletive / oath / swearing / swearword / cuss
curse (n.)
an appeal to some supernatural power to inflict evil on someone or some group;
curse (n.)
an evil spell;
a witch put a curse on his whole family
Synonyms: hex / jinx / whammy
curse (n.)
something causing misery or death;
Synonyms: bane / scourge / nemesis
curse (n.)
a severe affliction;
Synonyms: torment
2
curse (v.)
utter obscenities or profanities;
Synonyms: cuss / blaspheme / swear / imprecate
curse (v.)
heap obscenities upon;
The taxi driver who felt he didn't get a high enough tip cursed the passenger
curse (v.)
wish harm upon; invoke evil upon;
The bad witch cursed the child
Synonyms: beshrew / damn / bedamn / anathemize / anathemise / imprecate / maledict
curse (v.)
exclude from a church or a religious community;
Synonyms: excommunicate / unchurch
From wordnet.princeton.edu