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crisis (n.)

early 15c., crise, crisis, "decisive point in the progress of a disease," also "vitally important or decisive state of things, point at which change must come, for better or worse," from Latinized form of Greek krisis "turning point in a disease, that change which indicates recovery or death" (used as such by Hippocrates and Galen), literally "judgment, result of a trial, selection," from krinein "to separate, decide, judge," from PIE root *krei- "to sieve," thus "discriminate, distinguish."

Transferred non-medical sense is 1620s in English. A German term for "mid-life crisis" is Torschlusspanik, literally "shut-door-panic," fear of being on the wrong side of a closing gate.

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Definitions of crisis from WordNet

crisis (n.)
an unstable situation of extreme danger or difficulty;
they went bankrupt during the economic crisis
crisis (n.)
a crucial stage or turning point in the course of something;
after the crisis the patient either dies or gets better
From wordnet.princeton.edu