Etymology
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confuse (v.)

1550s in a literal sense "mix or mingle things or ideas so as to render the elements indistinguishable;" from mid-18c. in the active, figurative sense of "perplex the mind or ideas of, discomfit in mind or feeling," but not in general use until after c. 1800. From 1862 as "erroneously regard as identical." It took over these senses from its older doublet, confound (q.v.).

The past participle confused (q.v.) is attested much earlier, in Middle English (serving as an alternative past tense to confound), evidently an adaptation of Old French confus or Latin confusus, "with the native ppl. ending -ED and the present stem a much later inference from it" [OED]. Related: Confusing.

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Definitions of confuse

confuse (v.)
mistake one thing for another;
Synonyms: confound
confuse (v.)
be confusing or perplexing to; cause to be unable to think clearly;
These questions confuse even the experts
confuse (v.)
cause to feel embarrassment;
The constant attention of the young man confused her
Synonyms: flurry / disconcert / put off
confuse (v.)
assemble without order or sense;
Synonyms: jumble / mix up
confuse (v.)
make unclear, indistinct, or blurred;
Her remarks confused the debate
Synonyms: blur / obscure / obnubilate
From wordnet.princeton.edu