Etymology
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complication (n.)

early 15c., "complex combination or intricate intermingling," from Latin complicationem (nominative complicatio), noun of action from past participle stem of complicare "to fold together, fold up, roll up," from com "with, together" (see com-) + plicare "to fold, weave" (from PIE root *plek- "to plait").

From 1690s as "an additional disorder which develops during the course of an existing one," hence, generally, "that which renders (an existing situation) complex, involved, or intricate."

Complication commonly implies entanglement resulting either in difficulty of comprehension or in embarrassment; complexity, the multiplicity and not easily recognized relation of parts; as business complications; the complexity of a machine; the complexity of a question of duty. [Century Dictionary]

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Definitions of complication

complication (n.)
the act or process of complicating;
complication (n.)
a situation or condition that is complex or confused;
her coming was a serious complication
complication (n.)
any disease or disorder that occurs during the course of (or because of) another disease;
bed sores are a common complication in cases of paralysis
complication (n.)
a development that complicates a situation;
Synonyms: ramification
complication (n.)
puzzling complexity;
Synonyms: complicatedness / knottiness / tortuousness
From wordnet.princeton.edu