codeine (n.)

alkaloid present in opium, 1838, from French codéine, coined, with chemical suffix -ine (2), from Greek kodeia "poppy head," related to koos "prison," literally "hollow place;" kodon "bell, mouth of a trumpet;" koilos "hollow, hollowed out, spacious, deep," from PIE root *keue- "to swell," also "vault, hole." Originally codeina; modern form is from 1881.