Etymology
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antsy (adj.)

"restlessly impatient," 1838, American English, from plural of ant + -y (2); probably reflecting the same image as the slang expression have ants in (one's) pants "be restless and fidgety" from a century later. Related: Antsiness.

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Definitions of antsy

antsy (adj.)
nervous and unable to relax;
Synonyms: fidgety / fretful / itchy
From wordnet.princeton.edu