Etymology
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antagonist (n.)

"one who contends with another," 1590s, from French antagoniste (16c.) or directly from Late Latin antagonista, from Greek antagonistēs "competitor, opponent, rival," agent noun from antagonizesthai "to struggle against, oppose, be a rival," from anti "against" (see anti-) + agonizesthai "to contend for a prize," from agon "a struggle, a contest" (see agony). Originally in battle or sport, extended 1620s to any sphere of human activity.

updated on September 22, 2022

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Definitions of antagonist from WordNet

antagonist (n.)
someone who offers opposition;
Synonyms: adversary / opponent / opposer / resister
antagonist (n.)
a muscle that relaxes while another contracts;
when bending the elbow the triceps are the antagonist
antagonist (n.)
a drug that neutralizes or counteracts the effects of another drug;
Etymologies are not definitions. From wordnet.princeton.edu, not affiliated with etymonline.